ABSTRACT
Aim: COVID-19 is a cause of high-mortality pandemic with the RNA virus in its etiology and has an effect all over the world. In the present study, the relationship between in-hospital prognosis and mortality was investigated by comparing neutrophil-to-lymphocyte ratio (NLR), platelet –to-lymphocyte ratio (PLR) values with C-reactive protein (CRP) and with a detailed analysis of complete blood count and biochemical parameters in mild and severe COVID-19 cases.Method: A total of 271 patients who were diagnosed with pneumonia because of COVID-19 and 278 healthy control groups were included in the study. In our study, COVID-19 cases were divided into 2 groups as mild and severe, and the data were compared with healthy people without COVID-19. Lung tomography results of the cases that were diagnosed with COVID-19 were examined. Those with positive RT-PCR (Real-Time Polymerized Chain Reaction) test results were recorded from the system. Biochemical tests and complete blood count parameters of the patients, NLR/ lymphocyte- to- monocyte ratio (LMR)/PLR N/L, and CRP levels were compared with the control group. The results were evaluated and analyzed in statistical terms.Results:When all the data were analyzed, NLR/PLR and CRP levels were found to be higher at statistically significant levels in the severe patient group than in the control group, and LMR was lower (p<0.01). In ROC analysis, NLR/PLR and CRP had a high AUC (area under the curve) (0.844/0.719/0.501) and LMR had a low AUC (0.225).Conclusion: NLR and PLR might be useful in demonstrating the prognosis in severe COVID-19 cases.
ABSTRACT
The review is devoted to the peculiarities of the course of a new coronavirus infection (COVID-19) in elderly and senile patients. Data on the epidemiology, pathogenetic mechanisms of development, clinical manifestations, course and prognosis of the disease among geriatric patients are presented. The role of comorbid pathology in the course and prognosis of a new coronavirus infection in the elderly is shown. Recommendations for the treatment of patients with an emphasis on the need to comply with strict indications for prescribing antibacterial drugs in this category of patients are discussed. Copyright © 2022 Stavropol State Medical University. All rights reserved.